Lovastatin improves impaired synaptic plasticity and phasic alertness in patients with neurofibromatosis type 1

BACKGROUND: Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders causing learning disabilities by mutations in the neurofibromin gene, an important inhibitor of the RAS pathway. In a mouse model of NF1, a loss of function mutation of the neurofibromin gene resulted in increased...

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Detalhes bibliográficos
Main Authors: Mainberger, Florian, Jung, Nikolai H, Zenker, Martin, Wahlländer, Ute, Freudenberg, Leonie, Langer, Susanne, Berweck, Steffen, Winkler, Tobias, Straube, Andreas, Heinen, Florian, Granström, Sofia, Mautner, Victor-Felix, Lidzba, Karen, Mall, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015838/
https://ncbi.nlm.nih.gov/pubmed/24088225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2377-13-131
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