Optimising the radiolabelling properties of technetium tricarbonyl and His-tagged proteins

BACKGROUND: To date, the majority of protein-based radiopharmaceuticals have been radiolabelled using non-site-specific conjugation methods, with little or no control to ensure retained protein function post-labelling. The incorporation of a hexahistidine sequence (His-tag) in a recombinant protein...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Badar, Adam, Williams, Jennifer, de Rosales, Rafael TM, Tavaré, Richard, Kampmeier, Florian, Blower, Philip J, Mullen, Gregory ED
Format: Artigo
Langue:Inglês
Publié: Springer 2014
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015829/
https://ncbi.nlm.nih.gov/pubmed/24606843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-4-14
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