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Insulin gene mutations and diabetes
Some mutations of the insulin gene cause hyperinsulinemia or hyperproinsulinemia. Replacement of biologically important amino acid leads to defective receptor binding, longer half‐life and hyperinsulinemia. Three mutant insulins have been identified: (i) insulin Chicago (F49L or PheB25Leu); (ii) ins...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4015537/ https://ncbi.nlm.nih.gov/pubmed/24843467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.2040-1124.2011.00100.x |
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