Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

Increased endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) are the salient features of end-stage liver diseases. Using liver tissues from liver cirrhosis patients, we observed up-regulation of the XBP1–Hrd1 arm of the ER stress response pathway and down-regulation of the Nrf2-medi...

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Detalhes bibliográficos
Main Authors: Wu, Tongde, Zhao, Fei, Gao, Beixue, Tan, Can, Yagishita, Naoko, Nakajima, Toshihiro, Wong, Pak K., Chapman, Eli, Fang, Deyu, Zhang, Donna D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015486/
https://ncbi.nlm.nih.gov/pubmed/24636985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.238246.114
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