Report of a Phase I Evaluation of Dose and Schedule of Interleukin-1 Alpha and Cyclophosphamide in Patients with Advanced Tumors: An Eastern Cooperative Oncology Group Study (PX990) and Review of IL-1-Based Studies of Hematopoietic Reconstitution

Interleukin-1 (IL-1) is a cytokine critical to inflammation, immunological activation, response to infection, and bone marrow hematopoiesis. Cyclophosphamide downmodulates immune suppressor cells and is cytotoxic to a variety of tumors. A phase I trial of IL-1 and cyclophosphamide was conducted by t...

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Detalhes bibliográficos
Main Authors: Dutcher, Janice P., Neuberg, Donna, Atkins, Michael B., Tester, William J., Wadler, Scott, Stewart, James A., Chachoua, Abraham, Schuchter, Lynn M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015471/
https://ncbi.nlm.nih.gov/pubmed/24433038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2013.0010
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