Identification of CHRNA5 rare variants in African-American heavy smokers

The common CHRNA5 mis-sense coding single nucleotide polymorphism (SNP) rs16969968:G>A (D398N) has been shown repeatedly to confer risk for heavy smoking in individuals who carry the ‘A’ allele (encoding the 398N amino acid). The mis-sense SNP has a minor allele frequency (MAF) of ~40% in Europea...

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Main Authors: Doyle, Glenn A., Chou, Andrew D., Saung, Wint Thu, Lai, Alison T., Lohoff, Falk W., Berrettini, Wade H.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015337/
https://ncbi.nlm.nih.gov/pubmed/24682045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/YPG.0000000000000029
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