Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis

BACKGROUND: Principal component analysis (PCA) has been widely used to visualize high-dimensional metabolomic data in a two- or three-dimensional subspace. In metabolomics, some metabolites (e.g., the top 10 metabolites) have been subjectively selected when using factor loading in PCA, and biologica...

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Hlavní autoři: Yamamoto, Hiroyuki, Fujimori, Tamaki, Sato, Hajime, Ishikawa, Gen, Kami, Kenjiro, Ohashi, Yoshiaki
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015128/
https://ncbi.nlm.nih.gov/pubmed/24555693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-15-51
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