Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1(-/-) mice

BACKGROUND: Airway inflammation and airway remodeling are the key contributors to airway hyperresponsiveness (AHR), a characteristic feature of asthma. Both processes are regulated by Transforming Growth Factor (TGF)-β. Caveolin 1 (Cav1) is a membrane bound protein that binds to a variety of recepto...

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Hauptverfasser: Gabehart, Kelsa E, Royce, Simon G, Maselli, Diego J, Miyasato, Shelley K, Davis, Elaine C, Tang, Mimi LK, Jourdan Le Saux, Claude
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015038/
https://ncbi.nlm.nih.gov/pubmed/24138138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-110
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