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A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.

Site-specific mutagenesis of the self-splicing Tetrahymena intron has been used to investigate the function of C109-G212, a conserved base pair in the P4 stem of group I introns. Mutation of C109 to G affects splicing only slightly, whereas mutation of G212 to A or C reduces the rate of splicing sub...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Flor, P J, Flanegan, J B, Cech, T R
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1989
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC401485/
https://ncbi.nlm.nih.gov/pubmed/2684642
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