A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.

Site-specific mutagenesis of the self-splicing Tetrahymena intron has been used to investigate the function of C109-G212, a conserved base pair in the P4 stem of group I introns. Mutation of C109 to G affects splicing only slightly, whereas mutation of G212 to A or C reduces the rate of splicing sub...

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Argitaratua izan da:	EMBO J
Egile Nagusiak:	Flor, P J, Flanegan, J B, Cech, T R
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Publishing Group 1989
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC401485/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2684642/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb08503.x
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