A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.

Site-specific mutagenesis of the self-splicing Tetrahymena intron has been used to investigate the function of C109-G212, a conserved base pair in the P4 stem of group I introns. Mutation of C109 to G affects splicing only slightly, whereas mutation of G212 to A or C reduces the rate of splicing sub...

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Vydáno v:EMBO J
Hlavní autoři: Flor, P J, Flanegan, J B, Cech, T R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1989
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC401485/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2684642/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb08503.x
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