Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting.

Ubiquitin conjugation is a signal for degradation of eukaryotic proteins by the 26S protease. Conjugation of a homopolymeric multiubiquitin chain to a substrate lysine residue results in 10-fold faster degradation than does conjugation of monoubiquitin, but the molecular basis of enhanced targeting...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Beal, R, Deveraux, Q, Xia, G, Rechsteiner, M, Pickart, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.861
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