Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting.
Ubiquitin conjugation is a signal for degradation of eukaryotic proteins by the 26S protease. Conjugation of a homopolymeric multiubiquitin chain to a substrate lysine residue results in 10-fold faster degradation than does conjugation of monoubiquitin, but the molecular basis of enhanced targeting...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1996
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.861 |
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