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The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling

Interferons (IFNs) activate the first lines of defense against viruses, and promote innate and adaptive immune responses to viruses. We report that the immediate early 1 (IE1) protein of human cytomegalovirus (HCMV) disrupts signaling by IFNγ. The carboxyl-terminal region of IE1 is required for this...

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Hlavní autoři: Raghavan, Bindu, Cook, Charles H., Trgovcich, Joanne
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014707/
https://ncbi.nlm.nih.gov/pubmed/24699362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v6041502
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