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The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling

Interferons (IFNs) activate the first lines of defense against viruses, and promote innate and adaptive immune responses to viruses. We report that the immediate early 1 (IE1) protein of human cytomegalovirus (HCMV) disrupts signaling by IFNγ. The carboxyl-terminal region of IE1 is required for this...

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Detalhes bibliográficos
Main Authors: Raghavan, Bindu, Cook, Charles H., Trgovcich, Joanne
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014707/
https://ncbi.nlm.nih.gov/pubmed/24699362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v6041502
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