ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

Gambogic acid (GA), the main active component of gamboge resin, has potent antitumor activity both in vivo and in vitro. However, the underlying molecular mechanisms remain unclear. In this study, we found that GA could initiate autophagy in colorectal cancer cells, and inhibition of the autophagy p...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Haiyuan, Lei, Yunlong, Yuan, Ping, Li, Lingjun, Luo, Chao, Gao, Rui, Tian, Jun, Feng, Zuohua, Nice, Edouard C., Sun, Jun
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014500/
https://ncbi.nlm.nih.gov/pubmed/24810758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096418
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