Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.

Central to signaling by fibroblast growth factors (FGFs) is the oligomeric interaction of the growth factor and its high-affinity cell surface receptor, which is mediated by heparin-like polysaccharides. It has been proposed that the binding of heparin-like polysaccharides to FGF induces a conformat...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Venkataraman, G, Sasisekharan, V, Herr, A B, Ornitz, D M, Waksman, G, Cooney, C L, Langer, R, Sasisekharan, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40145/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570646/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.845
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