Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.

Central to signaling by fibroblast growth factors (FGFs) is the oligomeric interaction of the growth factor and its high-affinity cell surface receptor, which is mediated by heparin-like polysaccharides. It has been proposed that the binding of heparin-like polysaccharides to FGF induces a conformat...

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Bibliografiska uppgifter
Huvudupphovsmän: Venkataraman, G, Sasisekharan, V, Herr, A B, Ornitz, D M, Waksman, G, Cooney, C L, Langer, R, Sasisekharan, R
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1996
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC40145/
https://ncbi.nlm.nih.gov/pubmed/8570646
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