Fitness Impact and Stability of a Transgene Conferring Resistance to Dengue-2 Virus following Introgression into a Genetically Diverse Aedes aegypti Strain

In 2006, we reported a mariner (Mos1)-transformed Aedes aegypti line, Carb77, which was highly resistant to dengue-2 virus (DENV2). Carb77 mosquitoes expressed a DENV2-specific inverted-repeat (IR) RNA in midgut epithelial cells after ingesting an infectious bloodmeal. The IR-RNA formed double-stran...

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Main Authors: Franz, Alexander W. E., Sanchez-Vargas, Irma, Raban, Robyn R., Black, William C., James, Anthony A., Olson, Ken E.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014415/
https://ncbi.nlm.nih.gov/pubmed/24810399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002833
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