Fitness impact and stability of a transgene conferring resistance to dengue-2 virus following introgression into a genetically diverse Aedes aegypti strain.

In 2006, we reported a mariner (Mos1)-transformed Aedes aegypti line, Carb77, which was highly resistant to dengue-2 virus (DENV2). Carb77 mosquitoes expressed a DENV2-specific inverted-repeat (IR) RNA in midgut epithelial cells after ingesting an infectious bloodmeal. The IR-RNA formed double-stran...

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Main Authors: Alexander W E Franz, Irma Sanchez-Vargas, Robyn R Raban, William C Black, Anthony A James, Ken E Olson
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2014-05-01
Colecção:PLoS Neglected Tropical Diseases
Acesso em linha:http://europepmc.org/articles/PMC4014415?pdf=render
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