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Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti
Mosquitoes (Aedes aegypti) were genetically modified to exhibit impaired vector competence for dengue type 2 viruses (DENV-2). We exploited the natural antiviral RNA interference (RNAi) pathway in the mosquito midgut by constructing an effector gene that expresses an inverted-repeat (IR) RNA derived...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1449670/ https://ncbi.nlm.nih.gov/pubmed/16537508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600479103 |
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