A combined kinetic and modeling study of the catalytic center subsites of human angiogenin.
Kinetic analysis and molecular modeling have been used to map the ribonucleolytic center of angiogenin (Ang). Pyrimidine nucleotides were found to interact very weakly with Ang, consistent with the inaccessible B1 pyrimidine binding site revealed by x-ray crystallography. Ang also lacks an effective...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1996
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40137/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570639/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.804 |
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