Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.

The cell surface receptors for insulin and epidermal growth factor (EGF) both employ a tyrosine-specific protein kinase activity to fulfil their distinct biological roles. To identify the structural domains responsible for various receptor activities, we have generated chimeric receptor polypeptides...

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Vydáno v:	EMBO J
Hlavní autoři:	Riedel, H, Dull, T J, Honegger, A M, Schlessinger, J, Ullrich, A
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 1989
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC401363/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2583088/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb08444.x
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Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.

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