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Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.

The cell surface receptors for insulin and epidermal growth factor (EGF) both employ a tyrosine-specific protein kinase activity to fulfil their distinct biological roles. To identify the structural domains responsible for various receptor activities, we have generated chimeric receptor polypeptides...

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Udgivet i:EMBO J
Principais autores: Riedel, H, Dull, T J, Honegger, A M, Schlessinger, J, Ullrich, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC401363/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2583088/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb08444.x
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