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High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A
Niemann Pick disease type A (NPA), which is caused by loss of function mutations in the acid sphingomyelinase (ASM) gene, is a lysosomal storage disorder leading to neurodegeneration. Yet, lysosomal dysfunction and its consequences in the disease are poorly characterized. Here we show that undegrade...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4013520/ https://ncbi.nlm.nih.gov/pubmed/24488099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.4 |
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