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Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer’s disease
About 15 years ago it was proposed that generation of the truncated protein p25 contributes to toxicity in Alzheimer’s disease (AD). p25 is a calcium-dependent degradation product of p35, the principal activator of cyclin-dependent kinase 5 (Cdk5). The biochemical properties of p25 suggested that it...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4013459/ https://ncbi.nlm.nih.gov/pubmed/24822036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00036 |
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