Chargement en cours...

The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide

The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is known to play a role in sensitivity to temozolomide. Promoter hypermethylation of MGMT is commonly used to predict low expression levels of MGMT in gliomas, despite observed discordance between promoter methylation and protein...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Moen, Erika L., Stark, Amy L., Zhang, Wei, Dolan, M. Eileen, Godley, Lucy A.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013207/
https://ncbi.nlm.nih.gov/pubmed/24568970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0924
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!