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The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide

The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is known to play a role in sensitivity to temozolomide. Promoter hypermethylation of MGMT is commonly used to predict low expression levels of MGMT in gliomas, despite observed discordance between promoter methylation and protein...

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Autores principales: Moen, Erika L., Stark, Amy L., Zhang, Wei, Dolan, M. Eileen, Godley, Lucy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013207/
https://ncbi.nlm.nih.gov/pubmed/24568970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0924
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