Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo

Signal Transducer and Activator of Transcription-3 (STAT3) is constitutively activated in many cancers where it promotes growth, inflammation, angiogenesis and inhibits apoptosis. We have shown that STAT3 is constitutively activated in human gastric cancer, and that chronic IL-11-driven STAT3 transc...

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Hlavní autoři: Judd, Louise M., Menheniott, Treve R., Ling, Hui, Jackson, Cameron B., Howlett, Meegan, Kalantzis, Anastasia, Priebe, Waldemar, Giraud, Andrew S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013079/
https://ncbi.nlm.nih.gov/pubmed/24804649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095993
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