Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent

Lung CD4+ T cells accumulate as chronic obstructive pulmonary disease (COPD) progresses, but their role in pathogenesis remains controversial. To address this controversy, we studied lung tissue from 53 subjects undergoing clinically-indicated resections, lung volume reduction, or transplant. Viable...

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Main Authors: Freeman, Christine M., McCubbrey, Alexandra L., Crudgington, Sean, Nelson, Joshua, Martinez, Fernando J., Han, MeiLan K., Washko, George R., Chensue, Stephen W., Arenberg, Douglas A., Meldrum, Catherine A., McCloskey, Lisa, Curtis, Jeffrey L.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013040/
https://ncbi.nlm.nih.gov/pubmed/24805101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096421
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