Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent

Lung CD4+ T cells accumulate as chronic obstructive pulmonary disease (COPD) progresses, but their role in pathogenesis remains controversial. To address this controversy, we studied lung tissue from 53 subjects undergoing clinically-indicated resections, lung volume reduction, or transplant. Viable...

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Detalhes bibliográficos
Main Authors: Freeman, Christine M., McCubbrey, Alexandra L., Crudgington, Sean, Nelson, Joshua, Martinez, Fernando J., Han, MeiLan K., Washko, George R., Chensue, Stephen W., Arenberg, Douglas A., Meldrum, Catherine A., McCloskey, Lisa, Curtis, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013040/
https://ncbi.nlm.nih.gov/pubmed/24805101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096421
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