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Characterization of Ubiquitin-Activating Enzyme Uba1 in the Nucleus by Its Mammalian Temperature-Sensitive Mutant

Temperature-sensitive (ts) CHO-K1 mutant tsTM3 exhibits chromosomal instability and cell-cycle arrest in the S to G(2) phases with decreased DNA synthesis at the nonpermissive temperature, 39°C. Previously, complementation tests with other mutants showed that tsTM3 harbors a genetic defect in the ub...

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Autores principales: Sugaya, Kimihiko, Ishihara, Yoshie, Inoue, Sonoe, Tsuji, Hideo
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013028/
https://ncbi.nlm.nih.gov/pubmed/24805847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096666
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