Adrenomedullin up-regulates osteopontin and attenuates vascular calcification via the cAMP/PKA signaling pathway

AIM: To determine whether adrenomedullin (ADM) attenuates vascular calcification (VC) by inducing osteopontin (OPN) expression. METHODS: A VC model of rat aorta was induced with vitamin D3 plus nicotine (VDN), and vascular smooth muscle cell (VSMC) calcification was induced with beta-glycerophosphat...

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Hlavní autoři: Cai, Yan, Teng, Xu, Pan, Chun-shui, Duan, Xiao-hui, Tang, Chao-shu, Qi, Yong-fen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012911/
https://ncbi.nlm.nih.gov/pubmed/20802507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.89
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