Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus

Elevated expression of heat shock protein 90 (HSP90) has been found in kidneys and serum of systemic lupus erythematosus (SLE) patients and MRL/Mp-Fas(lpr)/Fas(lpr) (MRL/lpr) autoimmune mice. We investigated if inhibition of HSP90 would reduce disease in MRL/lpr mice. In vitro, pretreatment of mesan...

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Detalhes bibliográficos
Main Authors: Shimp, Samuel K, Chafin, Cristen B, Regna, Nicole L, Hammond, Sarah E, Read, Molly A, Caudell, David L, Rylander, MarissaNichole, Reilly, Christopher M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012849/
https://ncbi.nlm.nih.gov/pubmed/22543833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2012.5
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