Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint.

Catalytic RNA molecules, or ribozymes, have generated significant interest as potential therapeutic agents for controlling gene expression. Although ribozymes have been shown to work in vitro and in cellular assays, there are no reports that demonstrate the efficacy of synthetic, stabilized ribozyme...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Flory, C M, Pavco, P A, Jarvis, T C, Lesch, M E, Wincott, F E, Beigelman, L, Hunt, S W, Schrier, D J
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.754
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