Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint.

Catalytic RNA molecules, or ribozymes, have generated significant interest as potential therapeutic agents for controlling gene expression. Although ribozymes have been shown to work in vitro and in cellular assays, there are no reports that demonstrate the efficacy of synthetic, stabilized ribozyme...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Flory, C M, Pavco, P A, Jarvis, T C, Lesch, M E, Wincott, F E, Beigelman, L, Hunt, S W, Schrier, D J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.754
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