A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression

Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia (AML). Here, we identified a mechanism whereby a GATA2 distal hematopoietic enhancer (G2DHE or −77-kb enhancer) is brought into close proximity to the EVI1 gene in inv(3)(q21;q26) inversions, leading to leukemoge...

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Bibliographic Details
Main Authors: Yamazaki, Hiromi, Suzuki, Mikiko, Otsuki, Akihito, Shimizu, Ritsuko, Bresnick, Emery H., Engel, James Douglas, Yamamoto, Masayuki
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012341/
https://ncbi.nlm.nih.gov/pubmed/24703906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.02.008
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