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CNS Delivery and Pharmacokinetic Evaluations of DALDA Analgesic Peptide Analog Administered in Nano-Sized Oil-in-Water Emulsion Formulation

PURPOSE: Although neuro-active peptides are highly potent as central nervous system (CNS) therapeutics, their systemic delivery across the blood-brain barrier (BBB) is limited due to lack of permeability in the brain and rapid systemic metabolism. In this study, we aimed at enhancing the brain deliv...

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Autors principals: Shah, Lipa, Gattacceca, Florence, Amiji, Mansoor M.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012000/
https://ncbi.nlm.nih.gov/pubmed/24297071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1252-8
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