A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity

Preventing unfavorable graft-versus-host disease (GVHD) without inducing broad suppression of the immune system presents a major challenge of allogeneic hematopoietic stem cell transplantation. We developed a novel strategy to ameliorate GVHD while preserving graft-versus-tumor (GVT) activity by sma...

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Hlavní autoři: Shono, Yusuke, Tuckett, Andrea Z, Ouk, Samedy, Liou, Hsiou-Chi, Altan-Bonnet, Grégoire, Tsai, Jennifer J, Oyler, Jennifer E, Smith, Odette M, West, Mallory L, Singer, Natalie V, Doubrovina, Ekaterina, Pankov, Dmitry, Undhad, Chandresh V, Murphy, George F, Lezcano, Cecilia, Liu, Chen, O’Reilly, Richard J, van den Brink, Marcel RM, Zakrzewski, Johannes L
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011979/
https://ncbi.nlm.nih.gov/pubmed/24550032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0585
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