Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice

Peroxisome proliferator-activated receptor (PPAR)-α, a lipid-sensing transcriptional factor, serves an important role in lipotoxicity. We evaluated whether fenofibrate has a renoprotective effect by ameliorating lipotoxicity in the kidney. Eight-week-old male C57BLKS/J db/m control and db/db mice, d...

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Detalhes bibliográficos
Main Authors: Hong, Yu Ah, Lim, Ji Hee, Kim, Min Young, Kim, Tae Woo, Kim, Yaeni, Yang, Keun Suk, Park, Hoon Suk, Choi, Sun Ryoung, Chung, Sungjin, Kim, Hyung Wook, Kim, Hye Won, Choi, Bum Soon, Chang, Yoon Sik, Park, Cheol Whee
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011795/
https://ncbi.nlm.nih.gov/pubmed/24801481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096147
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