Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) accounts for 80–85% of lung cancer cases, and almost half of newly diagnosed patients have metastatic disease. Pemetrexed is a widely used drug for NSCLC and inhibits several folate-dependent enzymes including thymidylate synthase (TS). Increased expression of TS c...

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Bibliografiske detaljer
Main Authors: Kawabata, Shigeru, Chiang, Chun-Te, Tsurutani, Junji, Shiga, Hideaki, Arwood, Matthew L., Komiya, Takefumi, Gills, Joell J., Memmott, Regan M., Dennis, Phillip A.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011583/
https://ncbi.nlm.nih.gov/pubmed/24658085
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