Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors

Combinatorial targeted therapies are more effective in treating cancer by blocking by-pass mechanisms or inducing synthetic lethality. However, their clinical application is hampered by resistance and toxicity. To meet this important challenge, we developed and tested a novel concept of biomarker-gu...

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Detalhes bibliográficos
Main Authors: Sahin, Ozgur, Wang, Qingfei, Brady, Samuel W, Ellis, Kenneth, Wang, Hai, Chang, Chia-Chi, Zhang, Qingling, Priya, Preety, Zhu, Rui, Wong, Stephen T, Landis, Melissa D, Muller, William J, Esteva, Francisco J, Chang, Jenny, Yu, Dihua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011340/
https://ncbi.nlm.nih.gov/pubmed/24675532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.37
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