Prediction of Efficacy of Vabicaserin, a 5-HT(2C) Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model

A quantitative systems pharmacology model that combines in vitro/preclinical neurophysiology data, human imaging data, and patient disease information was used to blindly predict steady-state clinical efficacy of vabicaserin, a 5-HT(2C) full agonist, in monotherapy and, subsequently, to assess adjun...

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Detalhes bibliográficos
Main Authors: Liu, J, Ogden, A, Comery, T A, Spiros, A, Roberts, P, Geerts, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011163/
https://ncbi.nlm.nih.gov/pubmed/24759548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2014.7
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