siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats

AIM: Plasminogen activator inhibitor-1 (PAI-1) is involved in the progression of pulmonary fibrosis. The present study was undertaken to examine the effects on pulmonary fibrosis of silencing PAI-1 expression with small interfering RNA (siRNA) and to assess the possible underlying mechanisms. METHOD...

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Main Authors: Zhang, Yan-ping, Li, Wen-bin, Wang, Wei-li, Liu, Jian, Song, Shu-xia, Bai, Lin-lin, Hu, Yu-yan, Yuan, Ya-dong, Zhang, Min
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011146/
https://ncbi.nlm.nih.gov/pubmed/22659625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.39
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