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Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4(+) T Lymphocytes and Macrophages
Productive transcription of the integrated HIV-1 provirus is restricted by cellular factors that inhibit RNA polymerase II elongation. The viral Tat protein overcomes this by recruiting a general elongation factor, P-TEFb, to the TAR RNA element that forms at the 5’ end of nascent viral transcripts....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4011037/ https://ncbi.nlm.nih.gov/pubmed/24832049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology1010094 |
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