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Positive charges in the cytoplasmic domain of Escherichia coli leader peptidase prevent an apolar domain from functioning as a signal.

Leader peptidase, an integral transmembrane protein of Escherichia coli, requires two apolar topogenic elements for its membrane assembly: a 'hydrophobic helper' and an internal signal. The highly basic cytoplasmic region between these domains is a translocation poison sequence, which we h...

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Foilsithe in:EMBO J
Main Authors: Laws, J K, Dalbey, R E
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 1989
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC401099/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2676512/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb03618.x
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