Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages

Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor Spic is selectively expressed by RPM and is required for their development, but the physiologic stimulus inducing Spic is unknown. Here, we report that Spic also regulated the...

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Detaylı Bibliyografya
Asıl Yazarlar: Haldar, Malay, Kohyama, Masako, So, Alex Yick-Lun, Wumesh, KC, Wu, Xiaodi, Briseno, Carlos G., Satpathy, Ansuman T., Kretzer, Nicole M., Rajasekaran, Namakkal Soorappan, Wang, Li, Egawa, Takeshi, Igarashi, Kazuhiko, Baltimore, David, Murphy, Theresa L., Murphy, Kenneth M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010949/
https://ncbi.nlm.nih.gov/pubmed/24630724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.069
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