Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages

Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor Spic is selectively expressed by RPM and is required for their development, but the physiologic stimulus inducing Spic is unknown. Here, we report that Spic also regulated the...

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Autors principals: Haldar, Malay, Kohyama, Masako, So, Alex Yick-Lun, Wumesh, KC, Wu, Xiaodi, Briseno, Carlos G., Satpathy, Ansuman T., Kretzer, Nicole M., Rajasekaran, Namakkal Soorappan, Wang, Li, Egawa, Takeshi, Igarashi, Kazuhiko, Baltimore, David, Murphy, Theresa L., Murphy, Kenneth M.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010949/
https://ncbi.nlm.nih.gov/pubmed/24630724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.069
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