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Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor Spic is selectively expressed by RPM and is required for their development, but the physiologic stimulus inducing Spic is unknown. Here, we report that Spic also regulated the...
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Główni autorzy: | , , , , , , , , , , , , , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
2014
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010949/ https://ncbi.nlm.nih.gov/pubmed/24630724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.069 |
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