Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties

Mouse splenic marginal zone precursors (MZPs) differentiate into marginal zone B (MZB) cells under a signaling pathway involving Notch2 and its ligand, delta-like 1 ligand (Dll1). We report the identification of an MZP subset in the spleen of young children. These MZPs differentiate into MZ-like B c...

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Main Authors: Descatoire, Marc, Weller, Sandra, Irtan, Sabine, Sarnacki, Sabine, Feuillard, Jean, Storck, Sébastien, Guiochon-Mantel, Anne, Bouligand, Jérôme, Morali, Alain, Cohen, Joseph, Jacquemin, Emmanuel, Iascone, Maria, Bole-Feysot, Christine, Cagnard, Nicolas, Weill, Jean-Claude, Reynaud, Claude-Agnès
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010902/
https://ncbi.nlm.nih.gov/pubmed/24733829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132203
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