Thapsigargin blocks Pseudomonas aeruginosa homoserine lactone-induced apoptosis in airway epithelia

Pseudomonas aeruginosa secretes N-(3-oxododecanoyl)-homoserine lactone (C12) as a quorum-sensing molecule to regulate gene expression. Micromolar concentrations are found in the airway surface liquid of infected lungs. Exposure of the airway surface to C12 caused a loss of transepithelial resistance...

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Autori principali: Schwarzer, Christian, Ravishankar, Bharat, Patanwala, Maria, Shuai, Stacey, Fu, Zhu, Illek, Beate, Fischer, Horst, Machen, Terry E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010806/
https://ncbi.nlm.nih.gov/pubmed/24598360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00002.2014
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