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Role for high-glucose-induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis

Excess enzyme-mediated protein O-GlcNAcylation is known to occur with diabetes mellitus. A characteristic of diabetic cardiomyopathy is the development of myocardial fibrosis. The role that enhanced protein O-GlcNAcylation plays in modulating the phenotype of cardiac fibroblasts (CF) is unknown. To...

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Detalhes bibliográficos
Main Authors: Aguilar, Hugo, Fricovsky, Eduardo, Ihm, Sang, Schimke, Magdalena, Maya-Ramos, Lisandro, Aroonsakool, Nakon, Ceballos, Guillermo, Dillmann, Wolfgang, Villarreal, Francisco, Ramirez-Sanchez, Israel
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010805/
https://ncbi.nlm.nih.gov/pubmed/24553187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00251.2013
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