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Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies
A ubiquitous post-translational modification observed in proteins is isomerization of aspartic acid to isoaspartic acid (isoAsp). This non-enzymatic post-translational modification occurs spontaneously in proteins and plays a role in aging, autoimmune response, cancer, neurodegeneration, and other d...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010776/ https://ncbi.nlm.nih.gov/pubmed/24808864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00087 |
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